Ammonia → HCID 66669942, compound

HRID 1038686Notes

Reaction equation

HRID 1038686 reaction equation
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][CH3:9])[CH:3]=1.[NH2:10][C:11]1[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=1)[C:14]#[N:15].Cl.N>O.CO.CC(O)C>[CH3:9][NH:8][C:4]1[N:5]=[CH:6][N:7]=[C:2]([NH:10][C:11]2[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=2)[C:14]#[N:15])[CH:3]=1

Participants

8

Reactant 4

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 167023-AminobenzonitrileHCID 3094796-chloro-N-methylpyrimidin-4-amine

Product 1

HCID 66669942HCID 66669942, compound

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 962WaterSolventHCID 3776IsopropanolSolvent

Procedure

A mixture of (6-chloro-pyrimidin-4-yl)-methylamine (1.44 g, 10 mmol), 3-amino-benzonitrile. (1.18 g, 10 mmol), 2-propanol (10 mL) and conc. HCl (0.45 mL, ˜5 mmol) is stirred for 36 h at 90° C. After cooling to room temperature, CH3OH is added and the reaction mixture is basified with conc. aqueous ammonia solution. The precipitate which forms upon addition of H2O is filtered off, washed with H2O and dried in vacuo to afford the title compound.

Workup

  1. filtrationis filtered off
  2. washwashed with H2O
  3. customdried in vacuo

Sources & evidence

ORD record
ord-5c42ade4f2414fa59f3b3f0be07ce2be
Source dataset
uspto-grants-2013_10
Patent number
US08552002B2

Reaction notes

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