反应详情

温度

80 °C

A suspension of N-(4-fluoro-phenyl)-pyrimidine-4,6-diamine (408.4 mg, 2 mmol), 2,6-dichlorophenyl isocyanate (413.6 mg, 2.2 mmol) in dry dioxane (5 mL) is shaken for 14 h at 80° C. After cooling to 5° C. the suspension is filtered, the residue washed with half-saturated K2CO3 solution, H2O and acetone and dried in vacuo.

1. temperatureAfter cooling to 5° C. the suspension
2. filtrationis filtered
3. washthe residue washed with half-saturated K2CO3 solution, H2O and acetone
4. customdried in vacuo