1,3-Dichloro-2-isocyanatobenzene → 1-(2,6-Dichloro-phenyl)-3-[6-(4-fluoro-phenylamino)-pyrimidin-4-yl]-urea

Participants

Reaction Conditions

Reaction Steps

A suspension of N-(4-fluoro-phenyl)-pyrimidine-4,6-diamine (408.4 mg, 2 mmol), 2,6-dichlorophenyl isocyanate (413.6 mg, 2.2 mmol) in dry dioxane (5 mL) is shaken for 14 h at 80° C. After cooling to 5° C. the suspension is filtered, the residue washed with half-saturated K2CO3 solution, H2O and acetone and dried in vacuo.

Provenance & Evidence