反应详情

A solution of N-(3-chloro-phenyl)-N′-methyl-pyrimidine-4,6-diamine (Example 124A, 94 mg, 0.4 mmol) and 2,6-dimethylphenyl isocyanate (74 mg, 0.52 mmol) in diglyme was stirred at 80° C. for 18 h. The solvent is evaporated in vacuo, and the residue is purified by column flash chromatography on silica gel (ethyl acetate/hexane 1:2) to afford title compound (29 mg, 19

1. customThe solvent is evaporated in vacuo
2. customthe residue is purified by column flash chromatography on silica gel (ethyl acetate/hexane 1:2)