反应详情

N-(4-Dimethylaminomethyl-3-trifluoromethyl-phenyl)-pyrimidine-4,6-diamine (359 mg, 1.2 mmol) is dissolved in MeOH (12 mL) and treated with K2CO3 (6 mL of a 1N aqueous solution) at RT. The reaction is heated to reflux for 1.5 h until completion, cooled back to RT and concentrated. The residual oil is taken up in EtOAc and washed with brine. The organic layers are dried over Na2SO4, filtered and concentrated under reduced pressure. Drying under high vacuum gives the title compound as a yellow oil. ESI-MS: 219 [MH]+.

1. temperatureThe reaction is heated
2. temperatureto reflux for 1.5 h until completion
3. concentrationconcentrated
4. washwashed with brine
5. dry with materialThe organic layers are dried over Na2SO4
6. filtrationfiltered
7. concentrationconcentrated under reduced pressure
8. customDrying under high vacuum