Phosgene → 2,6-Dichloro-3-trifluoromethyl-phenylisocyanate
Reaction equation
[Cl:1][C:2]1[C:8]([C:9]([F:12])([F:11])[F:10])=[CH:7][CH:6]=[C:5]([Cl:13])[C:3]=1[NH2:4].[C:14](Cl)(Cl)=[O:15]>O1CCOCC1>[Cl:1][C:2]1[C:8]([C:9]([F:11])([F:10])[F:12])=[CH:7][CH:6]=[C:5]([Cl:13])[C:3]=1[N:4]=[C:14]=[O:15]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 100 °C
Procedure
To a solution of 2,6-dichloro-3-trifluoromethyl-aniline (138 mg, 0.60 mmol) in 2 ml of dioxane under a nitrogen atmosphere, phosgene (0.54 ml 20% in toluene, 1.0 mmol) is added. The mixture is stirred for 2 h at 100° C., cooled to rt and concentrated in vacuo, yielding 2,6-dichloro-3-trifluoromethyl-phenylisocyanate.
Workup
- temperaturecooled to rt
- concentrationconcentrated in vacuo
Sources & evidence
- ORD record
- ord-645a7975d0f64a6b91df5d19d6d4eb7a
- Source dataset
- uspto-grants-2013_10
- Patent number
- US08552002B2
Reaction notes
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