HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1038747Generated: October 31, 2026
Phosgene → 2,6-Dichloro-3-trifluoromethyl-phenylisocyanate
https://huagongshe.com/reaction/1038747
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosgene | HCID 6371 | — |
| Reactant | 2,6-Dichloro-3-(trifluoromethyl)aniline | HCID 13470473 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2,6-Dichloro-3-trifluoromethyl-phenylisocyanate | HCID 86630721 | — |
Reaction Steps
To a solution of 2,6-dichloro-3-trifluoromethyl-aniline (138 mg, 0.60 mmol) in 2 ml of dioxane under a nitrogen atmosphere, phosgene (0.54 ml 20% in toluene, 1.0 mmol) is added. The mixture is stirred for 2 h at 100° C., cooled to rt and concentrated in vacuo, yielding 2,6-dichloro-3-trifluoromethyl-phenylisocyanate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08552002B2 |
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| Source dataset | uspto-grants-2013_10 |
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| ORD ID | ord-645a7975d0f64a6b91df5d19d6d4eb7a |
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| Source note | uspto-grants-2013_10 |
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