4,5-Dichlorophthalic anhydride → HCID 42603377, compound

HRID 1038775Notes

Reaction equation

HRID 1038775 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][C:9]2[CH:10]=[C:11]3[C:15](=[CH:16][CH:17]=2)[N:14]([CH3:18])[C:13]([C:19]([N:21]2[CH2:26][CH2:25][N:24]([CH2:27][C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)[CH2:23][CH2:22]2)=[O:20])=[CH:12]3)=[N:6][CH:7]=1.[Cl:34][C:35]1[CH:36]=[C:37]2[C:42](=[O:43])[O:41][C:39](=[O:40])[C:38]2=[CH:44][C:45]=1[Cl:46]>ClCCCl>[CH2:27]([N:24]1[CH2:25][CH2:26][N:21]([C:19]([C:13]2[N:14]([CH3:18])[C:15]3[C:11]([CH:12]=2)=[CH:10][C:9]([O:8][C:5]2[N:6]=[CH:7][C:2]([NH:1][C:39](=[O:40])[C:38]4[C:37](=[CH:36][C:35]([Cl:34])=[C:45]([Cl:46])[CH:44]=4)[C:42]([OH:43])=[O:41])=[CH:3][CH:4]=2)=[CH:17][CH:16]=3)=[O:20])[CH2:22][CH2:23]1)[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1

Participants

4

Reactant 2

HCID 703344,5-Dichlorophthalic anhydrideHCID 68496097HCID 68496097, compound

Product 1

HCID 42603377HCID 42603377, compoundYield 100.8%

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

To a solution of [5-(5-aminopyridin-2-yloxy)-1-methyl-1H-indol-2-yl](4-benzylpiperazin-1-yl)methanone (1.00 g, 2.26 mmol) in 1,2-dichloroethane (22 mL) was added 4,5-dichlorophthalic anhydride (0.57 g, 2.62 mmol), and the mixture was stirred at room temperature for 4 hours. The resulting precipitate was collected by filtration and dried to give 1.5 g of the title compound as a white powder.

Workup

  1. filtrationThe resulting precipitate was collected by filtration
  2. customdried

Sources & evidence

ORD record
ord-b14c3f7df36b42a69f7494ccf23aea4f
Source dataset
uspto-grants-2013_10
Patent number
US08551999B2

Reaction notes

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