2-Pyridinecarboxaldehyde → HCID 2988171, compound

HRID 1038926Notes

Reaction equation

HRID 1038926 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH:7]=O.[CH3:9][C:10]1[N:19]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:18](=[O:26])[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=1>>[C:20]1([N:19]2[C:18](=[O:26])[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=[C:10]2[CH:9]=[CH:7][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 142732-PyridinecarboxaldehydeHCID 633784(3H)-Quinazolinone, 2-methyl-3-phenyl-

Product 1

HCID 2988171HCID 2988171, compoundYield 52%

Procedure

The title compound was synthesized according to General Procedure B using picolinaldehyde and compound 27. After cooling, the precipitate formed was filtered off, washed with water, dried and recrystallized from ethanol to yield compound 43 (0.49 g, 52%). M. Wt. 325. LCMS [M+H]+=326.

Workup

  1. customThe title compound was synthesized
  2. temperatureAfter cooling
  3. customthe precipitate formed
  4. filtrationwas filtered off
  5. washwashed with water
  6. customdried
  7. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-4930641b8dd0437d86e1cf31af57efaf
Source dataset
uspto-grants-2013_10
Patent number
US08552009B2

Reaction notes

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