HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethyl orthoacetate → 4(3H)-Quinazolinone, 2-methyl-3-(2-pyridyl)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethyl orthoacetate | HCID 66221 | — |
| Reactant | 2-amino-N-(pyridin-2-yl)benzamide | HCID 276325 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4(3H)-Quinazolinone, 2-methyl-3-(2-pyridyl)- | HCID 64049 | 75% |
Reaction Steps
A mixture of 72 (3 g, 0.015 mol) and 1,1,1-triethoxy-ethane (5 g, 0.045 mol) were heated for 7 hours. The reaction mixture was poured into water, filtered, and the precipitate was washed with water and recrystallized from EtOH to yield 73 (2.5 g, 75%). M. Wt. 237. LCMS [M+H]+=238.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08552009B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-60ff4eefaee94a2ba17fad36079ca815 |
| Source note | uspto-grants-2013_10 |