3-Bromo-1-methyl-1,2-dihydropyridin-2-one → 8-(1-Methyl-2-oxo-1,2-dihydropyridin-3-yl)-2-(4-(trifluoromethoxy)phenyl)-2,8-diazaspiro[4.5]decan-1-one
Reaction equation
[F:1][C:2]([F:22])([F:21])[O:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:14][CH2:13][C:12]3([CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)[C:11]2=[O:20])=[CH:6][CH:5]=1.Br[C:24]1[C:25](=[O:31])[N:26]([CH3:30])[CH:27]=[CH:28][CH:29]=1>>[CH3:30][N:26]1[CH:27]=[CH:28][CH:29]=[C:24]([N:17]2[CH2:16][CH2:15][C:12]3([C:11](=[O:20])[N:10]([C:7]4[CH:8]=[CH:9][C:4]([O:3][C:2]([F:1])([F:21])[F:22])=[CH:5][CH:6]=4)[CH2:14][CH2:13]3)[CH2:19][CH2:18]2)[C:25]1=[O:31]Participants
3
Procedure
The title compound was prepared in analogy to example 1 step D from a mixture of 2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one (described in example 1 step C) and 3-bromo-1-methyl-1H-pyridin-2-one. Light yellow solid. MS (ESI): 422.1 (MH+)
Sources & evidence
- ORD record
- ord-96ef13da4c8c4854af1154b5a1a40e4c
- Source dataset
- uspto-grants-2013_10
- Patent number
- US08552024B2
Reaction notes
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