3-Bromo-1-methyl-1,2-dihydropyridin-2-one → HCID 56655537, compound

HRID 1039013Notes

Reaction equation

HRID 1039013 reaction equation
[F:1][C:2]([F:24])([F:23])[C@H:3]([CH3:22])[O:4][C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:15][CH2:14][C:13]3([CH2:20][CH2:19][NH:18][CH2:17][CH2:16]3)[C:12]2=[O:21])=[CH:7][CH:6]=1.Br[C:26]1[C:27](=[O:33])[N:28]([CH3:32])[CH:29]=[CH:30][CH:31]=1>>[CH3:32][N:28]1[CH:29]=[CH:30][CH:31]=[C:26]([N:18]2[CH2:17][CH2:16][C:13]3([C:12](=[O:21])[N:11]([C:8]4[CH:9]=[CH:10][C:5]([O:4][C@@H:3]([CH3:22])[C:2]([F:1])([F:23])[F:24])=[CH:6][CH:7]=4)[CH2:15][CH2:14]3)[CH2:20][CH2:19]2)[C:27]1=[O:33]

Participants

3

Reactant 2

HCID 130240253-Bromo-1-methyl-1,2-dihydropyridin-2-oneHCID 58287255HCID 58287255, compound

Product 1

HCID 56655537HCID 56655537, compound

Procedure

The title compound was prepared in analogy to example 1 step D from a mixture of 2-[4-((S)-2,2,2-trifluoro-1-methylethoxy)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one (prepared in analogy to example 1 step B-C from 1-benzyl-4-(2-methoxyethyl)-piperidine-4-carboxylic acid ethyl ester and 4-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-phenylamine) and 3-bromo-1-methyl-1H-pyridin-2-one. Light green solid. MS (ESI): 450.1 (MH+)

Sources & evidence

ORD record
ord-a78fb90459ee4678985666fcda8fb4a7
Source dataset
uspto-grants-2013_10
Patent number
US08552024B2

Reaction notes

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