反应详情

2-{(1S,2R)-2-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethanol (176 mg, 0.63 mmol) from. Step 6, Example 2 was dissolved in dichloromethane (3 mL), then added triethylamine (190 mg, 1.87 mmol), 4-dimethylaminopyridine (15.3 mg, 0.13 mmol), last tosylchloride (167 mg, 0.87 mmol), stirred under N2 for 1.5 hours. The reaction solution was poured into ice water (10 mL), extracted with dichloromethane (10 mL×2). The organic phase was combined and dried by magnesium sulfate, filtered, then concentrated and purified by column chromatography through a 24 gram RediSep Rf™ silica gel cartridge eluting with 10% ethyl acetate/hexanes to give the title compound as a white solid.

1. extractionextracted with dichloromethane (10 mL×2)
2. dry with materialdried by magnesium sulfate
3. filtrationfiltered
4. concentrationconcentrated
5. custompurified by column chromatography through a 24 gram RediSep Rf™ silica gel cartridge
6. washeluting with 10% ethyl acetate/hexanes