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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1039062Generated: October 25, 2026

5-nitro-2-(1H-1,2,4-triazol-1-yl)pyridine → 6-(1H-1,2,4-Triazol-1-yl)pyridin-3-amine

https://huagongshe.com/reaction/1039062

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-nitro-2-(1H-1,2,4-triazol-1-yl)pyridineHCID 2766764—
CatalystPalladiumHCID 23938—
SolventMethanolHCID 887—
Product6-(1H-1,2,4-Triazol-1-yl)pyridin-3-amineHCID 16772327—

Reaction Steps

5-nitro-2-(1H-1,2,4-triazol-1-yl)pyridine (100 mg, 0.523 mmol) from step 1 of this example was added Pd/C (111 mg, 0.105 mmol) and methanol (5.2 mL). Set the reaction on Parr Shaker at 50 psi (345 kPa) for overnight. The solution was filtered through CELITE and rinsed with methanol to give the title compound as a white solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08552022B2
Source datasetuspto-grants-2013_10
ORD IDord-fbe714709af342a7b7b3c79361752d35
Source noteuspto-grants-2013_10