5-nitro-2-(1H-1,2,4-triazol-1-yl)pyridine → 6-(1H-1,2,4-Triazol-1-yl)pyridin-3-amine

HRID 1039062Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1039062
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH:14]=[N:13][CH:12]=[N:11]2)=[N:8][CH:9]=1)([O-])=O>[Pd].CO>[N:10]1([C:7]2[N:8]=[CH:9][C:4]([NH2:1])=[CH:5][CH:6]=2)[CH:14]=[N:13][CH:12]=[N:11]1

Komponenten

4

Edukt 1

HCID 27667645-nitro-2-(1H-1,2,4-triazol-1-yl)pyridine

Produkt 1

HCID 167723276-(1H-1,2,4-Triazol-1-yl)pyridin-3-amine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

5-nitro-2-(1H-1,2,4-triazol-1-yl)pyridine (100 mg, 0.523 mmol) from step 1 of this example was added Pd/C (111 mg, 0.105 mmol) and methanol (5.2 mL). Set the reaction on Parr Shaker at 50 psi (345 kPa) for overnight. The solution was filtered through CELITE and rinsed with methanol to give the title compound as a white solid.

Aufarbeitung

  1. customthe reaction on Parr Shaker at 50 psi (345 kPa) for overnight
  2. filtrationThe solution was filtered through CELITE
  3. washrinsed with methanol

Quellen und Nachweise

ORD-Eintrag
ord-fbe714709af342a7b7b3c79361752d35
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08552022B2

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