反应详情

2,5-Dichloropyrazine (298 mg, 2.0 mmol) and 1,2,4-triazole (145 mg, 2.1 mmol) were added in DMF (10 mL), then cesium carbonate was added and the reaction was at room temperature over night. Water (20mL) was added, extracted with ethyl acetate (30 mL), second wash with brine (20 mL). The organic phase was dried by magnesium sulfate, filtered, concentrated and purified by column chromatography through a 25 gram Biotage SNAP KP-Sil™ silica gel cartridge eluting with 22% ethyl acetate/hexanes to give the title compound as a white solid.

1. waitthe reaction was at room temperature over night
2. extractionextracted with ethyl acetate (30 mL)
3. washsecond wash with brine (20 mL)
4. dry with materialThe organic phase was dried by magnesium sulfate
5. filtrationfiltered
6. concentrationconcentrated
7. custompurified by column chromatography through a 25 gram Biotage SNAP KP-Sil™ silica gel cartridge
8. washeluting with 22% ethyl acetate/hexanes