Ethyl Acetate → HCID 55281286, Verbindung

HRID 1039121Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1039121
[NH:1]([C:3](=[S:6])OC)[NH2:2].[NH:7]1[CH2:12][CH2:11][CH:10]([OH:13])[CH2:9][CH2:8]1.C(OCC)(=O)C>C(O)C>[NH:1]([C:3]([N:7]1[CH2:12][CH2:11][CH:10]([OH:13])[CH2:9][CH2:8]1)=[S:6])[NH2:2]

Komponenten

5

Edukt 3

HCID 8857Ethyl AcetateHCID 79341Piperidin-4-olHCID 10171237O-methyl hydrazinecarbothioate

Produkt 1

HCID 55281286HCID 55281286, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

A solution of methyl hydrazinecarbothioate (1.0 g, 8.2 mmol) and piperidin-4-ol (1.24 g, 12.3 mmol) in ethanol (7 mL) was refluxed with heating at 90° C. for 2 days. After addition of ethyl acetate, the reaction solution was washed with saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate and concentrated to give the crude desired product. The crude product was used directly for the next reaction.

Aufarbeitung

  1. washthe reaction solution was washed with saturated aqueous sodium chloride
  2. dry with materialdried over anhydrous magnesium sulfate
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-ffdf41338bfb4baf90c4987ed35a4d2c
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08552031B2

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