Hydrochloric Acid → HCID 12132292, compound

HRID 1039389Notes

Reaction equation

HRID 1039389 reaction equation
[CH3:1][O:2][C:3]1[CH:25]=[CH:24][CH:23]=[CH:22][C:4]=1[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([C:13](=[O:21])[CH2:14][CH2:15][C:16]([O:18]CC)=[O:17])=[CH:9][CH:8]=1.[OH-].[Na+].Cl>C(O)C>[CH3:1][O:2][C:3]1[CH:25]=[CH:24][CH:23]=[CH:22][C:4]=1[CH2:5][O:6][C:7]1[CH:8]=[CH:9][C:10]([C:13](=[O:21])[CH2:14][CH2:15][C:16]([OH:18])=[O:17])=[CH:11][CH:12]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 21964526Ethyl 4-(4-(2-methoxybenzyloxy)phenyl)-4-oxobutyrate

Product 1

HCID 12132292HCID 12132292, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of Ethyl 4-(4-(2-methoxybenzyloxy)phenyl)-4-oxobutyrate (Step B, 1.49 g, 4.3 mmol) in abs ethanol (20 ml) was treated with 1N NaOH (6 ml). The reaction mixture was stirred at room temperature for 2 hours and then acidified with 1M HCl. The resulting white solid was filtered, washed with cold water and dried under vacuum to provide the title compound.

Workup

  1. filtrationThe resulting white solid was filtered
  2. washwashed with cold water
  3. customdried under vacuum

Sources & evidence

ORD record
ord-c4cf7648761b4f6cb819678f578471b7
Source dataset
uspto-grants-2013_10
Patent number
US08552062B2

Reaction notes

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