Benzaldehyde → N-Benzylethylenediamine

HRID 1039430Notes

Reaction equation

HRID 1039430 reaction equation
[CH2:1]([NH2:4])[CH2:2][NH2:3].[CH:5](=O)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>[Pd]>[CH2:5]([NH:3][CH2:2][CH2:1][NH2:4])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 240BenzaldehydeHCID 3301Ethylenediamine

Product 1

HCID 77801N-Benzylethylenediamine

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Benzylethylenediamine (Bz-EDA) was prepared by placing 250 g of ethylenediamine (4.16 moles) and 2.5 g of 5% Pd/C catalysts were placed in a stainless steel reactor under hydrogen pressure (800 psig) at 120° C. Benzaldehyde (441.7 g, 4.16 moles) were pumped inside the reactor over a period of an hour. The reaction was allowed to proceed for an extra hour. The reactor was then cooled down, the catalyst was removed by filtration to give the corresponding product.

Workup

  1. customwere placed in a stainless steel reactor under hydrogen
  2. customat 120° C
  3. waitto proceed for an extra hour
  4. temperatureThe reactor was then cooled down
  5. customthe catalyst was removed by filtration
  6. customto give the corresponding product

Sources & evidence

ORD record
ord-229689f342a5470baa080ec2c2ebbed7
Source dataset
uspto-grants-2013_10
Patent number
US08552078B2

Reaction notes

Loading…