反应详情

The above ester (0.34 g, 0.60 mmol) was dissolved in ethanol (30 mL), a solution of lithium hydroxide monohydrate (0.08 g, 1.9 mmol) in water (3 mL) was added and the mixture was left to stand for 48 h. The solvents were evaporated in vacuo; the residue was diluted with water (25 mL) and acidified with acetic acid (0.3 mL). The formed precipitate was filtered off and dried in the air yielding the title compound as amorphous solid.

1. waitthe mixture was left
2. customThe solvents were evaporated in vacuo
3. additionthe residue was diluted with water (25 mL)
4. filtrationThe formed precipitate was filtered off
5. customdried in the air