HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Glutaric anhydride → 4-[(4-Ethynylphenyl)carbamoyl]butanoic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Glutaric anhydride | HCID 7940 | — |
| Edukt | 4-Ethynylaniline | HCID 3760025 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | 4-[(4-Ethynylphenyl)carbamoyl]butanoic acid | HCID 24826477 | — |
Reaktionsschritte
To a solution of 4-ethynylaniline (0.99 g, 8.5 mmol) in CH2Cl2 (100 ml) is added glutaric anhydride (1.06 g, 9.30 mmol). After 1 h, the resulting slurry is concentrated by rotary evaporation and the crude mixture is purified by silica column chromatography (10% methanol/5% TEA/CH2Cl2).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08552173B2 |
| Quelldatensatz | uspto-grants-2013_10 |
| ORD ID | ord-9e4878eddd2240059eb2c5c6c7987521 |
| Quellennotiz | uspto-grants-2013_10 |