反应详情

To a solution of 4-ethynylaniline (0.99 g, 8.5 mmol) in CH2Cl2 (100 ml) is added glutaric anhydride (1.06 g, 9.30 mmol). After 1 h, the resulting slurry is concentrated by rotary evaporation and the crude mixture is purified by silica column chromatography (10% methanol/5% TEA/CH2Cl2).

1. concentrationthe resulting slurry is concentrated by rotary evaporation
2. customthe crude mixture is purified by silica column chromatography (10% methanol/5% TEA/CH2Cl2)