5-Hydroxypyridine-2-carboxylic acid → N-((R)-5-Bromoindan-2-yl)-5-hydroxypyridine-2-carboxamide

HRID 1039641Notes

Reaction equation

HRID 1039641 reaction equation
[OH:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[Br:11][C:12]1[CH:13]=[C:14]2[C:18](=[CH:19][CH:20]=1)[CH2:17][C@@H:16]([NH2:21])[CH2:15]2>>[Br:11][C:12]1[CH:13]=[C:14]2[C:18](=[CH:19][CH:20]=1)[CH2:17][C@@H:16]([NH:21][C:8]([C:5]1[CH:4]=[CH:3][C:2]([OH:1])=[CH:7][N:6]=1)=[O:10])[CH2:15]2

Participants

3

Reactant 2

HCID 2687405-Hydroxypyridine-2-carboxylic acidHCID 112758701H-Inden-2-amine, 5-bromo-2,3-dihydro-, (2R)-

Product 1

HCID 66679915N-((R)-5-Bromoindan-2-yl)-5-hydroxypyridine-2-carboxamide

Procedure

According to method C, 5-hydroxypyridine-2-carboxylic acid was reacted with (R)-5-bromo-indan-2-ylamine. This afforded the product with the molecular weight of 333.19 (C15H13BrN2O2); MS (ESI); 333 (M+H+).

Workup

  1. customThis afforded the product with the molecular weight of 333.19 (C15H13BrN2O2)

Sources & evidence

ORD record
ord-c518c434b15f46268b2410ee9a9d0637
Source dataset
uspto-grants-2013_10
Patent number
US08552199B2

Reaction notes

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