tert-Butanol → HCID 68007545, compound

HRID 1039801Notes

Reaction equation

HRID 1039801 reaction equation
[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[O:7][CH2:8][CH2:9][CH2:10][C:11](OC)=[O:12].[C:15]([OH:19])([CH3:18])([CH3:17])[CH3:16].C(OC(C)C)(C)C>[Zn]>[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[O:7][CH2:8][CH2:9][CH2:10][C:11]([O:19][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:12]

Participants

5

Reactant 3

HCID 6386tert-ButanolHCID 7914Diisopropyl EtherHCID 568187HCID 568187, compound

Product 1

HCID 68007545HCID 68007545, compoundYield 92.9%

Reagents, catalysts & solvents 1

HCID 23994ZincCatalyst

Procedure

Under a nitrogen atmosphere, a mixture of methyl 4-(tetrahydro-2H-pyran-2-yloxy)butyrate (3.0 mmol), t-butanol (3. 6 mmol), a zinc cluster Zn4O (OCOCF3)6 (0.0375 mmol) and diisopropyl ether (5.0 ml) was refluxed for 18 hours. As a result, t-butyl 4-(tetrahydro-2H-pyran-2-yloxy)butyrate was obtained in a yield of 92.9%.

Sources & evidence

ORD record
ord-7462cd34c52c46808da9533a0235164d
Source dataset
uspto-grants-2013_10
Patent number
US08552204B2

Reaction notes

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