反应详情

Synthesized according to the general procedure as described in Example 1a using D-phenylalanine methyl ester hydrochloride (2 gm, 9.2 mmol), THF (25 mL), MgSO4 (1.87 gm, 15.6 mmol), benzaldehyde (1.88 mL, 18.5 mmol), Et3N (1.28 mL, 9.2 mmol), sodium borohydride (699 mg, 18.5 mmol), and methanol (30 mL) to give 11g (1.8 gm, 72%) in FIG. 2. 1H NMR (500 MHz, CD3OD): δ 2.96 (2H, d, J=6.59 Hz), 3.53 (1H, t, J=7.08 Hz), 3.6 (3H, s), 3.63 (1H, d, J=12.93 Hz), 3.77 (1H, d, J=12.93 Hz), 7.13-7.18 (2H, m), 7.19-7.32 (8H, m). ESI-MS: 292.2 (M+23).

1. customSynthesized