反应详情

To a solution of 4-diethylamino-2-hydroxybenzaldehyde (300 mg, 1.55 mmol), pyridine (0.19 mL, 2.3 mmol) in 1.6 mL of dry dichloromethane was added benzoyl chloride (216 μL, 1.84 mmol) at 0° C. After being stirred at room temperature overnight, the reaction mixture was diluted with ethyl acetate. The mixture was washed with 1N HCl, saturated NaHCO3 aqueous solution, brine, and dried over MgSO4. After filtration, the filtrate was concentrated in vacuo, and the residue was purified by silica gel column chromatography (hexane/ethyl acetate=90/10 to 80/20) to obtain the title compound as a white solid (432 mg, 94%).

1. washThe mixture was washed with 1N HCl, saturated NaHCO3 aqueous solution, brine
2. dry with materialdried over MgSO4
3. filtrationAfter filtration
4. concentrationthe filtrate was concentrated in vacuo
5. customthe residue was purified by silica gel column chromatography (hexane/ethyl acetate=90/10 to 80/20)