Trifluoroacetic acid → HCID 86657584, compound

HRID 1040421Notes

Reaction equation

HRID 1040421 reaction equation
C(OC(=O)[NH:7][C:8]([C:11](=[O:13])[NH2:12])([CH3:10])[CH3:9])(C)(C)C.[F:15][C:16]([F:21])([F:20])[C:17]([OH:19])=[O:18]>ClCCl>[F:15][C:16]([F:21])([F:20])[C:17]([OH:19])=[O:18].[NH2:7][C:8]([CH3:10])([CH3:9])[C:11]([NH2:12])=[O:13]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 11287144tert-Butyl (1-amino-2-methyl-1-oxopropan-2-yl)carbamate

Product 1

HCID 86657584HCID 86657584, compoundYield 87.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of (1-carbamoyl-1-methyl-ethyl)-carbamic acid tert-butyl ester (945 mg, 4.67 mmol) in dichloromethane (20 mL) was added trifluoroacetic acid (10.0 mL, 64 mmol). The reaction mixture was stirred at room temperature for 4 h. The reaction mixture was then concentrated in vacuo to afford 882 mg of the title compound as a white solid, isolated as the TFA salt, m/z 103.2 [M+1]+.

Workup

  1. concentrationThe reaction mixture was then concentrated in vacuo

Sources & evidence

ORD record
ord-8a985cfb37f34a9ebf4343c9538a42b7
Source dataset
uspto-grants-2013_10
Patent number
US08552205B2

Reaction notes

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