Hydrochloric Acid → HCID 86657586, compound

HRID 1040427Notes

Reaction equation

HRID 1040427 reaction equation
C(OC([NH:8][NH:9][C:10]1([NH:13][C:14]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[S:15])[CH2:12][CH2:11]1)=O)(C)(C)C.[ClH:24]>O1CCOCC1>[ClH:24].[CH2:17]([O:16][C:14](=[S:15])[NH:13][C:10]1([NH:9][NH2:8])[CH2:11][CH2:12]1)[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86657588HCID 86657588, compound

Product 1

HCID 86657586HCID 86657586, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

N′-(1-benzyloxythiocarbonylamino-cyclopropyl)-hydrazinecarboxylic acid tert-butyl ester (0.25 g, 0.684 mmol) was dissolved in 4N HCl in dioxane (4 mL) and the reaction allowed to stir at room temperature overnight. The mixture was triturated with Et2O and the resulting precipitate collected by filtration. The precipitate was washed with Et2O to give (1-hydrazino-cyclopropyl)-thiocarbamic acid O-benzyl ester hydrochloride (0.15 g, 0.48 mmol) as a white solid, m/z 266.5 [M+H]+.

Workup

  1. customThe mixture was triturated with Et2O
  2. filtrationthe resulting precipitate collected by filtration
  3. washThe precipitate was washed with Et2O

Sources & evidence

ORD record
ord-be56fa22579246e2a30f7a0294aef4cb
Source dataset
uspto-grants-2013_10
Patent number
US08552205B2

Reaction notes

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