Hydrogen Bromide → HCID 67390587, compound

HRID 1040428Notes

Reaction equation

HRID 1040428 reaction equation
C(OC(=O)[NH:10][C:11]1([C:14]2[S:15][CH:16]=[N:17][N:18]=2)[CH2:13][CH2:12]1)C1C=CC=CC=1.CCOCC.[BrH:25]>C(O)(=O)C>[BrH:25].[S:15]1[CH:16]=[N:17][N:18]=[C:14]1[C:11]1([NH2:10])[CH2:13][CH2:12]1

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 3283Diethyl EtherHCID 58431249HCID 58431249, compound

Product 1

HCID 67390587HCID 67390587, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

(1-1,3,4-Thiadiazol-2-yl-cyclopropyl)-carbamic acid benzyl ester (0.2 g, 0.73 mmol) was dissolved in 48% HBr in acetic acid (5 mL) and allowed to stir for 30 min. Et2O was then added and the majority of the liquid decanted off. The remaining residue was concentrated under reduced pressure to give 1-1,3,4-thiadiazol-2-yl-cyclopropylamine hydrobromide (0.12 g, 0.54 mmol) as an orange gum, m/z 142.4 [M+H]+.

Workup

  1. customthe majority of the liquid decanted off
  2. concentrationThe remaining residue was concentrated under reduced pressure

Sources & evidence

ORD record
ord-21d68a2f31644e19a6703b8360b62727
Source dataset
uspto-grants-2013_10
Patent number
US08552205B2

Reaction notes

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