Hydroxylamine → HCID 178513433, compound
Reaction equation
[NH2:1][OH:2].[N:3]1([C:9]#[N:10])[CH2:8][CH2:7][O:6][CH2:5][CH2:4]1>CO.CCOCC>[OH:2][NH:1][C:9]([N:3]1[CH2:8][CH2:7][O:6][CH2:5][CH2:4]1)=[NH:10]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Conditions
- Temperature
- 80 °C
Procedure
A mixture of hydroxylamine (4.0 mL, 65 mmol) and morpholine-4-carbonitrile (5.00 g, 44.6 mmol) was heated at 80° C. for 24 h. After cooling to room temperature, the reaction mixture was diluted with MeOH and Et2O, then allowed to stand at room temperature for 2 days. The resultant precipitate was collected by filtration to give 9.02 g of the desired product as a white solid.
Workup
- temperatureAfter cooling to room temperature
- filtrationThe resultant precipitate was collected by filtration
Sources & evidence
- ORD record
- ord-7a3b4c50bca34ea7bf2964cc34e00f84
- Source dataset
- uspto-grants-2013_10
- Patent number
- US08552205B2
Reaction notes
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