1-(3-Ethyl-1,2,4-oxadiazol-5-yl)cyclopropan-1-amine hydrochloride → 1-[5-(1-Amino-cyclopropyl)-1,2,4-oxadiazol-3-yl]-propan-2-ol hydrochloride

HRID 1040434Notes

Reaction equation

HRID 1040434 reaction equation
[ClH:1].[NH2:2][C:3]1([C:6]2[O:10][N:9]=[C:8](N(C)C)[N:7]=2)[CH2:5][CH2:4]1.Cl.NC1(C2ON=C([CH2:24][CH2:25][OH:26])N=2)CC1.Cl.F[C:29](F)(F)CC1N=C(C2(N)CC2)ON=1.Cl.C(C1N=C(C2(N)CC2)ON=1)C.Cl.C(C1N=C(C2(N)CC2)ON=1)(C)C.Cl.CC1ON=C(C2(N)CC2)N=1.Cl.C(C1ON=C(C2(N)CC2)N=1)(C)C.Cl.C1(C2ON=C(C3(N)CC3)N=2)CC1>>[ClH:1].[NH2:2][C:3]1([C:6]2[O:10][N:9]=[C:8]([CH2:29][CH:25]([OH:26])[CH3:24])[N:7]=2)[CH2:5][CH2:4]1

Participants

9

Reactant 8

HCID 673896351-(3-Ethyl-1,2,4-oxadiazol-5-yl)cyclopropan-1-amine hydrochlorideHCID 673897542-[5-(1-Amino-cyclopropyl)-1,2,4-oxadiazol-3-yl]-ethanol hydrochlorideHCID 673899161-[3-(2,2,2-Trifluoro-ethyl)-1,2,4-oxadiazol-5-yl]-cyclopropylamine hydrochlorideHCID 673903191-(3-Isopropyl-1,2,4-oxadiazol-5-yl)-cyclopropylamine hydrochlorideHCID 673904321-(5-Methyl-1,2,4-oxadiazol-3-yl)cyclopropan-1-amine hydrochlorideHCID 673905391-(5-Cyclopropyl-1,2,4-oxadiazol-3-yl)cyclopropan-1-amine hydrochlorideHCID 67391075[5-(1-Amino-cyclopropyl)-1,2,4-oxadiazol-3-yl]-dimethyl-amine hydrochlorideHCID 673910791-(5-Isopropyl-1,2,4-oxadiazol-3-yl)-cyclopropylamine hydrochloride

Product 1

HCID 673902111-[5-(1-Amino-cyclopropyl)-1,2,4-oxadiazol-3-yl]-propan-2-ol hydrochloride

Procedure

The following compounds were prepared using similar procedures as described above: [5-(1-Amino-cyclopropyl)-1,2,4-oxadiazol-3-yl]-dimethyl-amine hydrochloride, 2-[5-(1-Amino-cyclopropyl)-1,2,4-oxadiazol-3-yl]-ethanol hydrochloride, 1-[3-(2,2,2-Trifluoro-ethyl)-1,2,4-oxadiazol-5-yl]-cyclopropylamine hydrochloride, 1-(3-Ethyl-1,2,4-oxadiazol-5-yl)-cyclopropylamine hydrochloride, 1-(3-Isopropyl-1,2,4-oxadiazol-5-yl)-cyclopropylamine hydrochloride, 1-(5-Methyl-1,2,4-oxadiazol-3-yl)-cyclopropylamine hydrochloride, 1-(5-Isopropyl-1,2,4-oxadiazol-3-yl)-cyclopropylamine hydrochloride, 1-(5-Cyclopropyl-1,2,4-oxadiazol-3-yl)-cyclopropylamine hydrochloride.

Workup

  1. customThe following compounds were prepared

Sources & evidence

ORD record
ord-cae9f8e6ae6749be9362f885c2b62400
Source dataset
uspto-grants-2013_10
Patent number
US08552205B2

Reaction notes

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