反应详情

温度

110 °C

To a round bottom flask was added (1-cyano-cyclopropyl)-carbamic acid benzyl ester (500 mg, 2.31 mmol) in DMF (4 ml), followed by the addition of NaN3 (195 mg, 3 mmol) and NH4Cl (161 mg, 3 mmol). The reaction mixture was stirred at 110° C. for 24 h. The reaction mixture was concentrated in vacuo. The residue was dissolved in EtOAc/water. The organic layer was separated, washed with brine, dried under any. Na2SO4, filtered and concentrated to afford 380 mg of [1-(1H-tetrazol-5-yl)-cyclopropyl]-carbamic acid benzyl ester as a off-white solid, m/z 260.8 [M+1]+.

1. concentrationThe reaction mixture was concentrated in vacuo
2. dissolutionThe residue was dissolved in EtOAc/water
3. customThe organic layer was separated
4. washwashed with brine
5. customdried under any
6. filtrationNa2SO4, filtered
7. concentrationconcentrated