反应详情

温度

90 °C

To a round bottom flask was added 1-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-4-yl]-cyclopropylamine (400 mg, 1.58 mmol) in EtOH (20 ml) and 3N HCl (15 ml). The reaction mixture was stirred at 90° C. for 4 h. The reaction mixture was concentrated in vacuo. The residue was purified by prepHPLC by eluting with 0.5% acetonitrile/water to afford 267 mg of 1-(1H-imidazol-4-yl)-cyclopropylamine as a formic acid salt, m/z 124 [M+1]+.

1. concentrationThe reaction mixture was concentrated in vacuo
2. customThe residue was purified by prepHPLC
3. washby eluting with 0.5% acetonitrile/water