Trifluoroacetic acid → Trifluoroacetic acid

HRID 1040465Notes

Reaction equation

HRID 1040465 reaction equation
C(OC(=O)[NH:7][C:8]1([C:11]2[NH:12][CH:13]=[C:14]([C:16]([F:19])([F:18])[F:17])[N:15]=2)[CH2:10][CH2:9]1)(C)(C)C.[C:21]([OH:27])([C:23]([F:26])([F:25])[F:24])=[O:22]>C(Cl)Cl>[F:19][C:16]([F:17])([F:18])[C:14]1[N:15]=[C:11]([C:8]2([NH2:7])[CH2:10][CH2:9]2)[NH:12][CH:13]=1.[C:21]([OH:27])([C:23]([F:26])([F:25])[F:24])=[O:22]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178452618HCID 178452618, compound

Product 2

HCID 6422Trifluoroacetic acidHCID 178507173HCID 178507173, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of [1-(4-Trifluoromethyl-1H-imidazol-2-yl)-cyclopropyl]-carbamic acid tert-butyl ester (32 mg, 0.11 mmol) in DCM (1 mL) was added TFA (500 uL). The clear solution was stirred at room temperature for overnight. Solvents were removed and the resulting materials were re-suspended in Toluene (15 mL) and concentrated down to dryness to provide the title compound 1-(4-Trifluoromethyl-1H-imidazol-2-yl)-cyclopropylamine as a TFA salt, m/z 192.41 [M+1]+

Workup

  1. customSolvents were removed
  2. concentrationconcentrated down to dryness

Sources & evidence

ORD record
ord-d3447d5ad3f54bfb9c0197309ce0747a
Source dataset
uspto-grants-2013_10
Patent number
US08552205B2

Reaction notes

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