Hydrochloric Acid → HCID 58431097, compound

HRID 1040467Notes

Reaction equation

HRID 1040467 reaction equation
C(OC(=O)[NH:7][C:8]1([C:11]2[N:16]=[C:15]3[NH:17][CH:18]=[CH:19][C:14]3=[CH:13][CH:12]=2)[CH2:10][CH2:9]1)(C)(C)C.Cl>O1CCOCC1>[NH:17]1[C:15]2=[N:16][C:11]([CH:8]([NH2:7])[CH2:9][CH3:10])=[CH:12][CH:13]=[C:14]2[CH:19]=[CH:18]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58431253HCID 58431253, compound

Product 1

HCID 58431097HCID 58431097, compoundYield 140.9%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of [1-(1H-Pyrrolo[2,3-b]pyridin-6-yl)-cyclopropyl]-carbamic acid tert-butyl ester (80 mg, 0.32 mmol) in dioxane (1 mL) was added 4N HCl in dioxane (500 uL, 2.00 mmol). The reaction was stirred at room temperature for 1 h. Solvents were removed and the resulting brown oil was suspended in Toluene (3 mL×2). Removal of solvents to dryness affords 79 mg of the title compound 1-(1H-Pyrrolo[2,3-b]pyridin-6-yl)-cyclopropylamine as a HCl salt, m/z 174.40 [M+1]+

Workup

  1. customSolvents were removed
  2. customRemoval of solvents to dryness

Sources & evidence

ORD record
ord-add804c8ff40485a8f956a0e6e515b2b
Source dataset
uspto-grants-2013_10
Patent number
US08552205B2

Reaction notes

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