Hydrochloric Acid → HCID 67390310, compound

HRID 1040473Notes

Reaction equation

HRID 1040473 reaction equation
C(OC(=O)[NH:7][C:8]1([C:11]2[N:16]=[CH:15][CH:14]=[CH:13][N:12]=2)[CH2:10][CH2:9]1)(C)(C)C.[ClH:18]>C(Cl)Cl>[ClH:18].[ClH:18].[N:12]1[CH:13]=[CH:14][CH:15]=[N:16][C:11]=1[C:8]1([NH2:7])[CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66570341tert-Butyl N-[1-(pyrimidin-2-yl)cyclopropyl]carbamate

Product 1

HCID 67390310HCID 67390310, compoundYield 79.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(1-Pyrimidin-2-yl-cyclopropyl)-carbamic acid tert-butyl ester (1.60 g, 6.80 mmol) was dissolved in CH2Cl2 (10 mL). HCl solution (4M in 1,4-dioxane, 17 mL, 68 mmol) was added via in one portion via syringe and the solution immediately became cloudy. The reaction was allowed to stir for 3 h. Solvents were removed in vacuo yielding a solid mass that was dried under vacuum to give 1.12 g of the title compound as a light yellow solid, m/z 136.32 [M+1]+.

Workup

  1. customSolvents were removed in vacuo
  2. customyielding a solid mass that
  3. customwas dried under vacuum

Sources & evidence

ORD record
ord-2dfa6bf601e04eacb51e76a2e2a5ac12
Source dataset
uspto-grants-2013_10
Patent number
US08552205B2

Reaction notes

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