HCID 178521698, compound → HCID 178507184, compound

HRID 1040485Notes

Reaction equation

HRID 1040485 reaction equation
C(OC(=O)[NH:10][C:11]1([C:14]2[NH:18][C:17]([CH:19]3[CH2:21][CH2:20]3)=[N:16][N:15]=2)[CH2:13][CH2:12]1)C1C=CC=CC=1>CO.[Pd]>[CH:19]1([C:17]2[NH:18][C:14]([C:11]3([NH2:10])[CH2:12][CH2:13]3)=[N:15][N:16]=2)[CH2:21][CH2:20]1

Participants

4

Reactant 1

HCID 178521698HCID 178521698, compound

Product 1

HCID 178507184HCID 178507184, compoundYield 99.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

[1-(5-Cyclopropyl-4H-[1,2,4]triazol-3-yl)-cyclopropyl]-carbamic acid benzyl ester (220 mg, 0.74 mmol) was dissolved in MeOH (40 mL) followed by the addition of 10% Pd/C. The solution mixture was stirred under H2 balloon for 1.5 hours. The reaction mixture was filtered through celite. The solvent was concentrated under high vacuum pump to afford 1-(5-Cyclopropyl-4H-[1,2,4]triazol-3-yl)-cyclopropylamine (120 mg, 0.73 mmol, 99.1%) as off-white solids.

Workup

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationThe solvent was concentrated under high vacuum pump

Sources & evidence

ORD record
ord-611e854596884301896e1607e2f1ebe7
Source dataset
uspto-grants-2013_10
Patent number
US08552205B2

Reaction notes

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