Trifluoroacetic acid → HCID 58431183, compound

HRID 1040491Notes

Reaction equation

HRID 1040491 reaction equation
C(OC(=O)[NH:7][C:8]1([C:11]2[CH:16]=[CH:15][C:14]([S:17]([CH3:20])(=[O:19])=[O:18])=[CH:13][N:12]=2)[CH2:10][CH2:9]1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:20][S:17]([C:14]1[CH:15]=[CH:16][C:11]([C:8]2([NH2:7])[CH2:10][CH2:9]2)=[N:12][CH:13]=1)(=[O:19])=[O:18]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58431216HCID 58431216, compound

Product 1

HCID 58431183HCID 58431183, compoundYield 250.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

[1-(5-Methanesulfonyl-pyridin-2-yl)-cyclopropyl]-carbamic acid tert-butyl ester (148 mg, 0.47 mmol) was dissolved in DCM (4 mL). TFA (2 mL) was added dropwise. After 4 h, the reaction was concentrated in-vacuo to yield 250 mg of crude 1-(5-methanesulfonyl-pyridin-2-yl)-cyclopropylamine as a TFA salt (dark oil), m/z=213.3 [M+1]+. The product was used in subsequent reactions without further purification.

Workup

  1. concentrationthe reaction was concentrated in-vacuo

Sources & evidence

ORD record
ord-ad054b0928d74e01a053efbcaf99430a
Source dataset
uspto-grants-2013_10
Patent number
US08552205B2

Reaction notes

Loading…