Hydrogen Bromide → HCID 67390371, compound

HRID 1040498Notes

Reaction equation

HRID 1040498 reaction equation
C(OC(=O)[NH:10][C:11]1([C:14]2[N:18]=[C:17]([C:19]([F:22])([F:21])[F:20])[O:16][N:15]=2)[CH2:13][CH2:12]1)C1C=CC=CC=1.[BrH:24]>C(O)(=O)C.CCOCC>[BrH:24].[F:22][C:19]([F:20])([F:21])[C:17]1[O:16][N:15]=[C:14]([C:11]2([NH2:10])[CH2:12][CH2:13]2)[N:18]=1

Participants

5

Reactant 2

HCID 260Hydrogen BromideHCID 58431168Phenylmethyl N-[1-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]cyclopropyl]carbamate

Product 1

HCID 67390371HCID 67390371, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 3283Diethyl EtherSolvent

Procedure

[1-(5-Trifluoromethyl-1,2,4-oxadiazol-3-yl)-cyclopropyl]-carbamic acid benzyl ester (0.22 g, 0.67 mmol) was dissolved in 33% HBr in acetic acid (0.5 mL) and the reaction allowed to stir for 30 min at RT. The mixture was diluted with Et2O resulting is formation of a white precipitate. The majority of the liquid was decanted off and the residue concentrated under reduce pressure to give 1-(5-trifluoromethyl-1,2,4-oxadiazol-3-yl)-cyclopropylamine hydrobromide (0.19 g, 0.69 mmol) as an orange solid.

Workup

  1. customThe majority of the liquid was decanted off
  2. concentrationthe residue concentrated

Sources & evidence

ORD record
ord-3b90b03dad954bc28afbde542ef15ae3
Source dataset
uspto-grants-2013_10
Patent number
US08552205B2

Reaction notes

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