Hydrochloric Acid → {1-[1-(4-Aminomethyl-pyridin-2-yl)-cyclopropylcarbamoyl]-cyclopropyl}-carbamic acid benzyl ester dihydrochloride

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Reaction Steps

4M HCl solution in 1,4-dioxane (15 mL) was added to (1-{1-[4-(tert-Butoxycarbonylamino-methyl)-pyridin-2-yl]-cyclopropylcarbamoyl}-cyclopropyl)-carbamic acid benzyl ester (1.403 g, 2.92 mmol). The resultant mixture was allowed to stir at RT for 6 h. The mixture was concentrated to afford a light brown solid. This solid was washed with diethyl ether and dried in vacuo to afford 1.271 g of {1-[1-(4-Aminomethyl-pyridin-2-yl)-cyclopropylcarbamoyl]-cyclopropyl}-carbamic acid benzyl ester di-hydrochloric acid salt.

Provenance & Evidence