反应详情

4M HCl solution in 1,4-dioxane (15 mL) was added to (1-{1-[4-(tert-Butoxycarbonylamino-methyl)-pyridin-2-yl]-cyclopropylcarbamoyl}-cyclopropyl)-carbamic acid benzyl ester (1.403 g, 2.92 mmol). The resultant mixture was allowed to stir at RT for 6 h. The mixture was concentrated to afford a light brown solid. This solid was washed with diethyl ether and dried in vacuo to afford 1.271 g of {1-[1-(4-Aminomethyl-pyridin-2-yl)-cyclopropylcarbamoyl]-cyclopropyl}-carbamic acid benzyl ester di-hydrochloric acid salt.

1. concentrationThe mixture was concentrated
2. customto afford a light brown solid
3. washThis solid was washed with diethyl ether
4. customdried in vacuo