Trifluoroacetic acid → Trifluoroacetic acid

HRID 1040718Notes

Reaction equation

HRID 1040718 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][C:10](=[O:13])[NH:11][CH3:12])(C)(C)C.[F:15][C:16]([F:21])([F:20])[C:17]([OH:19])=[O:18]>ClCCl>[NH2:7][CH2:8][CH2:9][C:10]([NH:11][CH3:12])=[O:13].[C:17]([OH:19])([C:16]([F:21])([F:20])[F:15])=[O:18]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 15546845HCID 15546845, compound

Product 2

HCID 6422Trifluoroacetic acidHCID 14889074N-Methyl-beta-alaninamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(2-Methylcarbamoyl-ethyl)-carbamic acid tert-butyl ester (534 mg, 2.64 mmol) was dissolved in dichloromethane (10 mL) and the solution was treated with trifluoroacetic acid (3 mL). The reaction was allowed to stir overnight at room temperature. The solvent and excess TFA was then concentrated to afford 3-Amino-N-methyl-propionamide as a crude TFA salt. The crude material (270 mg) was used without further purification.

Workup

  1. concentrationThe solvent and excess TFA was then concentrated

Sources & evidence

ORD record
ord-7c228b50352c4dc79a47aea0d73b95f3
Source dataset
uspto-grants-2013_10
Patent number
US08552186B2

Reaction notes

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