3-Ethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamine → HCID 131730897, compound

HRID 1040722Notes

Reaction equation

HRID 1040722 reaction equation
C(N1CCC2C=C(N)C=CC=2CC1)C.[Cl:15][C:16]1[C:17]([NH:36][C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][C:38]=2[C:43]2[N:44]([CH3:48])[CH:45]=[CH:46][N:47]=2)=[N:18][C:19]([NH:22][C:23]2[CH:24]=[CH:25][C:26]3[CH2:32][CH2:31][C:30]([F:34])([F:33])[CH2:29][CH2:28][C:27]=3[CH:35]=2)=[N:20][CH:21]=1.FC1(F)CCC2C=C(N)C=CC=2CC1>>[Cl:15][C:16]1[C:17]([NH:36][C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][C:38]=2[C:43]2[N:44]([CH3:48])[CH:45]=[CH:46][N:47]=2)=[N:18][C:19]([NH:22][C:23]2[CH:24]=[CH:25][C:26]3[CH2:32][CH2:31][C:30]([F:34])([F:33])[CH2:29][CH2:28][C:27]=3[CH:35]=2)=[N:20][CH:21]=1

Participants

3

Reactant 2

HCID 189434013-Ethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamineHCID 131730898HCID 131730898, compound

Product 1

HCID 131730897HCID 131730897, compound

Procedure

Example 219 was synthesized analogously to Example 216 replacing 3-Ethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamine with 7,7-Difluoro-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-ylamine 5-Chloro-N*2*-(7,7-difluoro-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl)-N*4*-[2-(1-methyl-1H-imidazol-2-yl)-phenyl]-pyrimidine-2,4-diamine was isolated as a foam. LC/MS (ESI)=481.96 (M+H). 1H NMR (400 MHz, DMSO, d6) δ 9.09 (m, 2H), 8.12 (s, 1H), 7.74 (m, 5H), 7.56 (m, 1H), 7.41 (s, 1H), 7.26 (m, 1H), 6.99 (d, 1H, J=8.09 Hz), 3.61 (s, 3H), 2.67 (m, 2H), 2.50 (m, 2H), 1.96 (m, 4H).

Workup

  1. customwas isolated as a foam

Sources & evidence

ORD record
ord-531f3777c3934625955e688fab277e76
Source dataset
uspto-grants-2013_10
Patent number
US08552186B2

Reaction notes

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