反应详情

2-fluoro-6-nitrobenzoic acid methyl ester (4.54 g, 22.8 mmol), ethylenediamine (1.50 mL, 22.4 mmol) and diisopropylethylamine (8.71 mL, 50 mmol) were dissolved in 1,4-dioxane (40 mL). The reaction mixture was then irradiated at 140° C. for 40 minutes. After cooling, the reaction mixture was poured over saturated ammonium chloride (50 mL), and organics were extracted with ethyl acetate (3×50 mL). The combined organic extracts were dried over Na2SO4, filtered and reduced. The residue was then purified by flash column chromatography (0% MeOH/DCM-20% MeOH/DCM over 35 minutes) to afford 1.2 grams of 6-Nitro-1,2,3,4-tetrahydro-benzo[e][1,4]diazepin-5-one as a yellow oil. LC/MS (ESI)=208.24 (M+H).

1. customThe reaction mixture was then irradiated at 140° C. for 40 minutes
2. temperatureAfter cooling
3. extractionorganics were extracted with ethyl acetate (3×50 mL)
4. dry with materialThe combined organic extracts were dried over Na2SO4
5. filtrationfiltered
6. customThe residue was then purified by flash column chromatography (0% MeOH/DCM-20% MeOH/DCM over 35 minutes)