Tetrahydrofuran → HCID 67264023, compound

HRID 1041113Notes

Reaction equation

HRID 1041113 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([N+:18]([O-:20])=[O:19])=[C:7]([N:9](S(C)(=O)=O)[S:10]([CH3:13])(=[O:12])=[O:11])[CH:8]=1.O1CCCC1.[OH-].[Na+]>O>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([N+:18]([O-:20])=[O:19])=[C:7]([NH:9][S:10]([CH3:13])(=[O:12])=[O:11])[CH:8]=1

Participants

5

Reactant 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 67264251HCID 67264251, compound

Product 1

HCID 67264023HCID 67264023, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of N-(5-Methoxy-2-nitro-phenyl)-N-(methylsulfonyl) methanesulfonamide (7.70 g) in Tetrahydrofuran (200 mL, 2 mol) was added 1 M of Sodium hydroxide in Water (50 mL). The mixture was stirred for 18 hours. The mixture was poured into a separatory funnel and the aqueous layer (bottom layer) was separated. The aqueous layer was washed with Ethyl Acetate (100 mL). The organic layers were combined, dried over magnesium sulfate, filtered and evaporated. N-(5-Methoxy-2-nitro-phenyl)-methanesulfonamide isolated as an orange solid (5.59 g, 76%).

Workup

  1. additionThe mixture was poured into a separatory funnel
  2. customthe aqueous layer (bottom layer) was separated
  3. washThe aqueous layer was washed with Ethyl Acetate (100 mL)
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. customevaporated

Sources & evidence

ORD record
ord-15aa1684822c49bab3925171697ee03c
Source dataset
uspto-grants-2013_10
Patent number
US08552186B2

Reaction notes

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