HCID 67264073, compound → HCID 67263981, compound

HRID 1041712Notes

Reaction equation

HRID 1041712 reaction equation
[CH:1]([N:4]1[C:10]2[CH:11]=[C:12]([N+:15]([O-])=O)[CH:13]=[CH:14][C:9]=2[O:8][CH2:7][CH2:6][CH2:5]1)([CH3:3])[CH3:2]>[Pd].CO>[CH:1]([N:4]1[C:10]2[CH:11]=[C:12]([NH2:15])[CH:13]=[CH:14][C:9]=2[O:8][CH2:7][CH2:6][CH2:5]1)([CH3:3])[CH3:2]

Participants

4

Reactant 1

HCID 67264073HCID 67264073, compound

Product 1

HCID 67263981HCID 67263981, compoundYield 98%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

9-Isopropyl-2-nitro-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocycloheptene (0.128 g, 0.000542 mol), 10% Palladium on Carbon (50% Wet) (0.023 g). and Methanol (0.57 mL) was shaken under an atmosphere of Hydrogen at 40 psi overnight. Filtration and conc. afforded 9-Isopropyl-6,7,8,9-tetrahydro-5-oxa-9-aza-benzo-cyclohepten-2-ylamine as a brown oil (109 mg, 98%). LCMS: 206.

Workup

  1. filtrationFiltration

Sources & evidence

ORD record
ord-bff4405d17024657a2625c0d5e9d23ae
Source dataset
uspto-grants-2013_10
Patent number
US08552186B2

Reaction notes

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