Tetrahydrofuran → HCID 178519734, compound

Participants

Reaction Steps

To a solution of 1-benzyloxy-6-carboxy-2 (1H)-pyridinone (4.90 g, 20 mmol), 2-mercaptothiazoline (2.62 g, 22 mmol), and a catalytic amount of 4-dimethyl-aminopyridine (DMAP) in dry THF (50 mL), was added N,N′-dicyclohexylcarbodiimide (DCC) (4.6 g, 22 mmol). After stirring overnight, the dicyclohexylurea (DCU) solids are removed by filtration the yellow filtrate is removed by rotary evaporation to give a yellow solid. Crystallization from isopropanol-methylene chloride gives the title compound (5.80 g, 83.7%) as a pale yellow powder, m.p.: 135-7° C.

Provenance & Evidence