Diethylamine → 2-(Benzyloxy)-N,N-diethylacetamide

HRID 1041836Notes

Reaction equation

HRID 1041836 reaction equation
[CH2:1]([O:8][CH2:9][C:10](Cl)=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:13]([NH:15][CH2:16][CH3:17])[CH3:14]>C(Cl)Cl>[CH2:1]([O:8][CH2:9][C:10]([N:15]([CH2:16][CH3:17])[CH2:13][CH3:14])=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 177085Benzyloxyacetyl chloride

Product 1

HCID 606458502-(Benzyloxy)-N,N-diethylacetamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

At 0° C., 1.54 ml (9.7 mmol) of benzyloxyacetyl chloride and 0.92 ml (8.9 mmol) of diethylamine were dissolved in 35 ml of CH2Cl2. The reaction mixture was stirred at room temperature (RT) for 2 hours and then washed with dilute HCl solution and saturated NaCl solution. The organic phase was dried over Na2SO4 and evaporated to dryness. 2-(Benzyloxy)-N,N-diethylacetamide was obtained as a colorless residue.

Workup

  1. washwashed with dilute HCl solution and saturated NaCl solution
  2. dry with materialThe organic phase was dried over Na2SO4
  3. customevaporated to dryness

Sources & evidence

ORD record
ord-aa16f1bcc6644eeda168c830efe93596
Source dataset
uspto-grants-2013_10
Patent number
US08557741B2

Reaction notes

Loading…