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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1041837Generated: November 1, 2026

2-(Benzyloxy)-N,N-diethylacetamide → N,N-Diethyl-2-hydroxyacetamide

https://huagongshe.com/reaction/1041837

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Benzyloxy)-N,N-diethylacetamideHCID 60645850—
CatalystPalladiumHCID 23938—
SolventEthyl AcetateHCID 8857—
ProductN,N-Diethyl-2-hydroxyacetamideHCID 4137580—

Reaction Steps

2.20 g (9.9 mmol) of 2-(benzyloxy)-N,N-diethylacetamide were dissolved in 45 ml of ethyl acetate, and 200 mg of Pd/C (10%) were added. The reaction mixture was stirred under an atmosphere of hydrogen for 24 hours and then filtered through kieselguhr. The filtrate was evaporated to dryness, and N,N-diethyl-2-hydroxyacetamide was obtained as a colorless residue.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08557741B2
Source datasetuspto-grants-2013_10
ORD IDord-c4389c5a181347da859a63925e12a99d
Source noteuspto-grants-2013_10