2-(Benzyloxy)-N,N-diethylacetamide → N,N-Diethyl-2-hydroxyacetamide

HRID 1041837Notes

Reaction equation

HRID 1041837 reaction equation
C([O:8][CH2:9][C:10]([N:12]([CH2:15][CH3:16])[CH2:13][CH3:14])=[O:11])C1C=CC=CC=1>C(OCC)(=O)C.[Pd]>[CH2:13]([N:12]([CH2:15][CH3:16])[C:10](=[O:11])[CH2:9][OH:8])[CH3:14]

Participants

4

Reactant 1

HCID 606458502-(Benzyloxy)-N,N-diethylacetamide

Product 1

HCID 4137580N,N-Diethyl-2-hydroxyacetamide

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

2.20 g (9.9 mmol) of 2-(benzyloxy)-N,N-diethylacetamide were dissolved in 45 ml of ethyl acetate, and 200 mg of Pd/C (10%) were added. The reaction mixture was stirred under an atmosphere of hydrogen for 24 hours and then filtered through kieselguhr. The filtrate was evaporated to dryness, and N,N-diethyl-2-hydroxyacetamide was obtained as a colorless residue.

Workup

  1. filtrationfiltered through kieselguhr
  2. customThe filtrate was evaporated to dryness

Sources & evidence

ORD record
ord-c4389c5a181347da859a63925e12a99d
Source dataset
uspto-grants-2013_10
Patent number
US08557741B2

Reaction notes

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